Who knew... There is a medical distinction between “guts” and “balls”. We've heard colleagues referring to people with “guts”, or with “balls”. Do they, however, know the difference between them? Here’s the official distinction; straight from the British Medical Journal: Volume 323; page 295. GUTS - Is arriving home late, after a night out with the lads, being met by your wife with a broom and having the “guts” to ask: “Are you still cleaning, or are you flying somewhere?” BALLS - Is coming home late after a night out with the lads, smelling of perfume and beer, lipstick on your collar, slapping your wife on the bum and having the “balls” to say: 'You're next, Chubby.' I trust this clears up any confusion. Medically speaking, there is no difference in outcome; both are fatal.