Guessing this is a large can of worms.............and the PC obvious answer is no based on my DSC1 course......however in the real world things are different.
Assuming you are capable of the shot of course, would you take a shot at fairly close quarters end on? ( a reverse texas heart shot)
Lets say for example, you are crouching in a field of wheat and deer comes straight to you at 40 metres. You either take the shot then or he makes a rapid retreat.