I took a 416 Rem to Africa and took Gemsbok. Kudu, Zebra and smaller game up to 360 yards with 350gr Speer soft points - one shot one kill on them all.
At the risk of being verbally assaulted from all comers, stick a muzzle brake on it and make the recoil quite manageable.
My tin hat is on now and I'm ready for the inevitable flak from all who know better. However, I know I have shot with a brake on mine for years and all the p&£h that I get from those who know better is just that - p&£h.
Good hunting my man.
The trouble is that over here in the Uk, not many own a 416 and even fewer will have it licenced for use on British deer. About the biggest we can get licensed is the 375 H&H for everyday use on deer. To get answers ask our friends in the big bore forums on NitroExpress.com welcomes you to nitro express and big bore and big game action or http://www.accuratereloading.com.
I'm a member of Nitro express, but not sure how many are using it for red deer and who is shooting it enough to make some reasonable conclusions. If/When I get my barrel out of customs I'll be posting the what I find out here for educational purposes.
Cheers I'm particularly interested in how how far they travelling after a chest shot in the 100 to 150m ranges. I'm also interested in the blood trail compared to a 30-06. Either way the answers have be useful and ill fo my own tests soon hopefully.