I think you need to give us a hint on bullet weights that you want to use. I suggest a browse of the Hornady manual and you may get some ideas there. In my limited experience, I have found no benefits on majoring on one powder, instead I now focus on the bullets I would like to use and try 2 or 3 of the recommended powders for that bullet weight. Currently I have N165, N160, RL-19, RL-22, H4831 and H4350 in the cupboard. 3 of these are part tubs that I have got hold of to try out. Good luck. JCS