They are undoubtedly extremely well made bullets
i had them in .270
i am however not convinced they are proportionally better than any other high end bullet for the money they cost!
any decent bonded or locked cup and core bullet in .243 in an appropriate weight/velocity should result in acceptable terminal ballistics on game in that weight class (when you stick it somewhere sensible obviously!)
IMO meat damage is caused by a number of things, namely:
too light/too fast,
poor bullet construction choice for the task or for the velocity,
poor shot placement/visualisation of expected path,
variable aspects of striking bones and deflecting
Lighter bullets on heavy for calibre game require more attention (ability!) to shot placement and an advanced knowledge of anatomy and physiology of the target species.
WDM Bell favoured the 7x57 for elephant, but he had an extremely advanced knowledge of elephant cranial anatomy