Was using 85 grn Sierra bullets with ( a worked up load of ) 42 grn of H380, and it was a superb load - IN MY RIFLE...
However, one day I picked the incorrect box of bullets from the cabinet, and loaded 100grn bullets with the same powder load. I walked away from the firing of the first round it with a bruised right jaw, and a black eye, and a note to self to double check everything before the components are reloaded.
Good bullet, and good powder, but only needs small increments to change performance. I now use IMR 4350, for the .243, and am finding that a excellent powder aswell.
All the best.
Neil.