Years ago, a friend and I put together a .300 Whisper on a Thompson single shot with a 24 inch barrel, for taking deer in populated areas, where they were coming from a park and eating gardens. With the 200-gr Sierra MK, we could wait until a car passed on a highway nearby for taking the shot, and no one knew we were there. All the deer fell in their tracks.
Another friend, a gunsmith and designer with several patents, builds them on an AR platform with an integral suppressor - much fun to shoot, and can reach out there with 125-gr bullets.