In 1910 a North Indian sqaw shot and killed a Grizzly bear with a 22rf, three shots in the head, she was hunting squirrels when the bear attacked her, some reports said the bear actually fell dead on top of her, although this was latter thought to be a dramatization of the original story.
While hunting in NZ a couple of years ago our guide used two Hornets one with a scope one open sighted for all his hunting including red deer and Boar, he had 11 other CF rifles to choose from, but he said all were no more dead than when shot with a Hornet so long as you hit them in the lug hole.
ATB
Tahr