I have been using a Sauer 202 "variable" (Ithink you mean "switch barrel") barrel rifle for the last 15 years and it's never missed a beat. Having said that, I've not had the barrel off it more than a couple of times, just to, a) to see how quickly it could come off and go on again, and b) to see if the point of impact changed afterwards. Thae answers were, a) very quickly, and b) No.
I was going to get a second barrel and bolt for it in 243 the other year, but finances meant it was more feasible for me at the time to buy a complete second rifle instead. A second hand Winchester Mod 70 with mod and scope was only £100 dearer then the secondhand barrel and bolt I was looking at.