I bought a .25-06 (Sako 75) about 5 years ago, and my .243 has barely seen the light of day since.
Flatter for longer shots, and more knock down power, meaning very few runners. Have used it on all spceies, save CWD, with no issues.
For info, I use Federal Premium 100 grain, and havn't had much problem getting hold of them, though I tend to give the dealers a bit of notice before I need them, and then buy 200 at a time.