I have had a 1 - 12 twist 22-250 (Savage) plus a further three 22-250's, all of which I reloaded for, and I don't like H380.
I found it dirty and quite temperature sensitive giving varying POI's (put "H380 temperature sensitive into Google"?) and after many trials with several powders I much prefer Varget as a great all round powder for the 22-250.