I use a 25-06 rifle with 100gr bullets. This was recommended to me by several gunsmiths / suppliers over a 270 / 6.5x55 etc. Earlier this week, I was stalking with someone who uses a 270 with 110gr bullets. I might be missing something, but as both cartridges are based on the same case and both are firing almost the same weight bullet, is there any real difference between the two? If this is the case, then what is the advantage of the 25-06, unless you wish to use smaller bullets and have to re-zero for different quarries? I am not planning to change anything, just interested.