Lets be practical instead of "expert". You have a 243win & might start to reload & you want something a wee bit smaller. I have chosen the 22 250 as my little centerfire simply because it has the same head size ( see which end the head is actually on everyone) as the 30 06 family of cartridges which includes the 243 & it uses large rifle primers instead of small. It not just simplifies reloading, but those little small rifle primers get harder to fiddle with as the eyes & fingers get older. Who says a 22 250 has to be pushed harder than a 222? For me the 22 250 is a pest gun & I dont mind dropping the speed down a bit as I get better penetration on larger animals & I only use the case because of the large primer & head size not the increased case capacity.