Hi James.
I have a Drone pro on my 22-250, this sits at 2.6" high off the bore, because the scope is higher than normal this will give a further secondary zero.
I use home loaded Nosler 50g bt's and estimate their speed to be doing around 3570 feet per second, i initially zeroed mine at 1" high at 100yds, but i was finding that shooting foxes at a typical 150 yds a lot of my shots were going too high so i lowered the Drone Pro two clicks ----or there abouts, since then iv'e been hitting most cleanly from 50yds -240 yds aiming dead on, i dont really need to shoot foxes much over this distance so cannot really comment on drop/hold over past 240 yds.
Most centre fire rifles are at their highest point in trajectory at around 150 yds, therefore IMO you dont want to be "ANY MORE" than 1" high at 150 yds because if you aim just a little bit too high or pull the shot a little high you'll be going over the top of the fox like i was.
The Drone Pro adjusts owt from 1/2"-3/4" per click so you've to adjust to the nearest click to suite, check your rifle at 150 yds and adjust to the nearest click to give you not more than 1", this is what i've got and its point-n-shoot out to 240 yds.
Dave (warbucks)