In principle, having just one rifle (22wmr) to cover .22 subsonic, to .22 high velocity seams great.
I tried it with LR sub, and LR Hyper Velocity.
At short range it was fine but, given the different trajectory of each, I found emembering holdover at 100m or so was tricky.
I don't know the velocity of wmr, presumably it's faster that the LR HV, so the difference in trajectory will be greater.
I guess if you're at short range it will be manageable.
May be experiment with your 22LR and some Hyper Vel ammo 1st.
M