Much depends, on eg how aware or otherwise the deer are to your presence, point of impact, deer's own intentions, i.e. Whether it is relaxed, at rest, heading to, at or from feeding, not to mention numerous other factors, topped off with fact that every deer being an individual is different. Having only thirty years behind the .243 with a good seven or eight years earlier using the .222, my findings lead me to believe that a) there is no set rule per se, and b) the factors touched upon above cannot be ignored or set aside as if to be of no influence.