I can't advise about using it with a 270, but I can tell you that H380 is the powder of choice for the 22.250, I believe it's named because of it.
If RL 19 is working for you stick with it, I can't see the savings being that much?
According to my Nosler manual H380 is listed with 130 bullets, starting from 46 grains and maximum of 50 grains, giving 77% case volume and 2932 fps.