You won't get nearly the velocity with 1680, that you do with Lil' Gun. And Lil'Gun prefers SPP's...When I converted over to small rifle primers I didn't see any change in group size. Just in case anybody was wondering.
Also AA1680 is a good powder for the hornet if you haven't tried it . In west Tennessee where I live it is easier to find than Lil-Gun or H110/296 right now.
In fact, I'd argue that Lil'Gun is the only reason the venerable old .22 Hornet is even still around and is as popular as it is in the US.