I suppose that new knowledge has come from research with equipment that can monitor wound channels more accurately? It's good to know, but a .458 hole will always be better than a .375 hole as long as the shooter can place the bullet with the same accuracy.The current bullets available for dangerous game are head and shoulders better than the cup and core bullets from last century. In soft nosed format you have the excellent Swift AFrame, the Trophy bonded bearclaw, the Cutting Edge Safari Raptor, the North Fork, Peregrine and the Barnes TSX. Solid bullet design has come on leaps and bounds from the round nosed solids to the cup nosed and flat nosed solids like the Cutting Edge Safari solids that penetrate far deeper and straighter than round nosed bullets. One test compared a slightly heavier monolithic round nosed bullet with a slightly lighter flat nosed bullet fired at the same velocity and the flat nosed bullet penetrated one metre deeper than the round nose into wet newspaper!
I wonder what the results would be between PH's and hunters with extensive use of big bores under their belts? I've shot hundreds of rounds through my .416 now and if I'm honest with myself as well as everyone else, I could pick up a .375 and shoot it better, no question. I think too many hunters go on dangerous game hunts before they are properly prepared. I'm getting better and intend to use a scoped .416, but I'm not ready yet.