As Scotty was prone to say in Star Trek - "ye cannae change the laws o physics"
It's the amount of energy that's transferred into the target from the bullet that does the damage and the higher the energy available at the point of impact, the more will be transferred to the target
Assuming all the 140ftlbs energy from a 17 HMR bullet is transferred to the target (unlikely) and only 20% of the 1250 ftlbs from the 22-250 bullet (more likely then the 22-250 is still dumping almost twice as much energy into the target and is therefore more likely to kill it
Cheers
Bruce
No one is trying to change physics here buddy.
It's just a different view.
It is not the energy that kills the critter. The critter does via a drastic drop in blood pressure or via a disruption to the central nervous system resulting in asphyxiation and or cardiac arrest.
Anything moving has kinetic energy. More is not better and less is not worse. Enough is enough and anymore is simply wasted energy.
For example electric kettles years ago took a lot longer than a modern one. Just because the new ones boil water quicker the out come is just the same.
I think you will find that the original concept for all the super fast 22's was not to increase energy and killing supremacy. You will find it was to boost range and wind cheating ability.
Flip it on its head. Ever wonder while a little 22 rimfire penetrates so well? Easy, the equal and opposite force acting on it is less.
So a faster bullet with by default higher kinetic values also has much more higher forces acting against it. Add water as it is present in flesh, water that does not like compressing you soon arrive at a point where upon the bullet may as well be hitting concrete!
Energy is meaningless if you have little or no control over it. It is not linear. Dead is dead, there is no deader than dead. There is only ever wounding if it is not dead.
That my friend is not decided by a ft/lb value.