Having had 2 tight twist 22.250 rifle and currently having a 8 twist 22 BR, I can tell you from experience that the combination of the larger 22.250 case , behind a high BC bullet is an awesome combination.
There are too many naysayers that are too quick to dismiss something which they have little experience of, and obviously are not aware of what a properly turned out 22.250 can do , when firing high BC bullets .
For vermin shooting out to 600 yrds it is one of the best calibres I have used. One only need do the maths to see that shooting a 77 grn TMK at 3300fps will out perform most things. The 22.250 had a ballistic advantage on both my 6BR and 243 at these ranges
Another tick in the box for me , is that an 8 or 9 twist 22.250 will also shoot 53 / 55 grain pills with no loss of accuracy. So what we end up with , is one of the best foxing calibres on the planet - that is more than capable of consistently taking out long range vermin. A calibre that has quality reloading components that are easily to get hold of and a huge choice of factory ammo if needed.
I am aware there are several manufactures the produce factory rifles with a 9 twist, Savage (model 12) and the Bergara HMR being the most obvious. Other than that, get an 8 twist custom tube fitted and enjoy.