To be honest, the 222 has big following on this site , or at least a very vocal group of enthusiasts.

But the truth is , out of the three main dominant 22 CF's ( i.e 222 - 223 + 22.250 ) the old treble is by FAR the least popular over here too.
The 222s closest neighbour - the 223, has almost killed new sales of the 222 in many places , as it is better ballistically and more importantly has a far wider selection of rifles - ammo - barrel twist rates ect which the treble cant match. The 222 is still an excellent calibre and I don't think any fox would know that difference in them.
Earlier on this this thread - a velocity of 3600fps was quoted for the 22.250 firing a 50 g bullet. This is of course massively downloaded for the 22.250 .
The reality is , there are factory ammo that shoot a 50 grn Vmax at 4000fps - and from my own experience I ran my 22.250 at speeds over 3900 fps without pressure signs from a 20 inch barrel.
Many years ago , My shooting buddy and I , would kill between 300 and 400 fox per year ( these were shot mostly with 223 and 22.250 )
Performance wise , I would guess that the 22.250 gives an additional 700 to 800 fps over a 222 with a 50 grn pill.
The extra velocity equates to LESS drop and LESS wind drift in the field,. This makes hitting the kill zone easier in field conditions , when the wind is blowing and there is no time to range find the distance between you and your quarry. The 22.250 also hits noticeably harder than either the 222 or 223 and this can mean less runners. For the record the bullet fired from a 22.250 carries more energy and 120Yrds - than the 222 does at the muzzle.
The downside is of course the 22.250 will cost more to feed and barrel life is shorter. .. but is this an issue as a fox / deer rifle ??? . A 22.250 barrel may last over 2000 rounds before accuracy starts to suffer in any noticeable way. . So that a lot of vermin / hunting. The extra noise is a non starter for me - mods are that good these days that you would be difficult to tell which CF your firing from a hundred yrds away.
Anyway , surprisingly , I am in the 22.250 camp
Alan