Sorry but it's the complete opposite, a light bullet pushed too fast will blow up, possibly without reaching the vitals. Slow bullets are far more likely to pencil as they lack the impact velocity to open them up. Following your logic the 204 Ruger would be the perfect Cape buffalo round.
Bullet choice is a compromise between expansion and penetration, velocity increases expansion and reduces penetration, (due to the increased expansion). So you want enough velocity to give expansion but enough weight to give adequate penetration. Then you have bullet construction to take into account. A really soft bullet, Vmax for example, fired at high velocity at a large animal may explode in the first 6 inches of flesh and fail to reach the vitals. Fire the same bullet at the same velocity at a small animal and you could blow it to bits. Fire that bullet at a medium sized animal and it might be perfect.. you need to match the calibre, velocity, and bullet to the game that you are looking for.
This is an age old conundrum, it is what spawned the 'premium' bullets like the Nosler partitions. A soft front half mated with a solid rear half, this is supposed to give you the best of both worlds; rapid expansion for lighter animals and deep penetration for heavier game....