Just my personal experience, so take it with a grain of salt, but I ran a load for 6.5CM at 2650fps, due to the last powder shortage. I had to use AA-4350, which runs a lot slower than H-4350.
At any rate, that load was so finicky, I finally gave up. Scott Satterlee had a theory, which has mostly held true, that a given case volume and bullet weight has a sweet spot, velocity wise. And that the 6.5CM was at 2850fps. Didn't matter what powder or bullet, everything just seemed to shoot reasonably well at that velocity node with a 140gr bullet.
That seemed to mirror what I was seeing when running that 2650fps load. It would shoot fine in calm winds, at distance. But as wind increased, I started to notice some erratic accuracies. I still can't explain why, but after moving to a powder that kept velocities up in the 2850'ish range, the flyers went away. H-4350, RL-15/16; it didn't matter, it just shot well. <shrug> It may be correlation doesn't equal causation, but it was an odd thing to see, and since, I have always run loads in that velocity node, without any accuracy issues.