Potential MMM in vizsla

Gm81

Well-Known Member
Our Viz is 4 in August. Has always been healthy and is a strong dog.
He got what we thought was an eye on infection in his right eye in march 2021 Swells up and looks sore. He was shivering like he had a fever and was looking pretty sorry for himself. Treated with antibiotic and metacam and went away. This happened again in July 2021 and same signs but I noticed he couldn't pick things up the same with his mouth. Very slight though. Same treatment and no understanding of what it could be by the vet.
June 2022 his left eye swelled up like the second time in the right. Metacam and antibiotics again.
I noticed his jaw not being the same. Can't carry a sock anything this time. I had a good look at his gums and teeth. All looks perfect and uniform gum colour. Press his face and head anywhere and no pain reaction. If I open his mouth over half way he yelps. So is in pain. Took him to the vet and she checked him over and agreed with my check over. I suggested MMM ( as the vets were inconclusive of his previous visits). Also I googled vizsla can't open his mouth properly and swollen eye. The vet said his head has suffered muscle loss one side but I thought it was the other side swollen. She admitted she knew nothing about the MMM but said he was obviously losing muscle and it looked fitting. Had a blood test visit was £290. 3 weeks later test was inconclusive/borderline.
He made a bit of recovery over the last few weeks with retrieving and carrying things. But he still can't yawn properly. Last night his eye has swollen a little. Mouth is not working properly and can't carry anything. Wet food to eat as well. Where his spine meets his head, the bone is becoming more prominent. Between his ear and eyes is starting to sink inwards. So he is losing muscle fast. Now I really think we have an issue with MMM. The muscle loss in 4 weeks is alarming to see.
Again speak to the vet, she isn't sure as she hasn't ever seen it and so we seem to twiddle our thumbs again. She spoke to the pet hospitals. Muscle biopsy that was suggested the labs can't test. Then derby want to carry out tests quoting £4500-£6500 for diagnostics. Donnington was looking less invasive and wanted to check him when he was looking ill. We were told £350. This is doable, but that was just to walk in the door. Then if the specialist wants him checking they said £3400 on top and pay in full before leaving.
Solihull were yet to give a price. But it's to far. They all said they were very interested in treating him. No discounts offered for them learning or researching though. I did ask.
Abscesses and infections have been said. But it swaps sides and we are getting muscle loss. So I don't know if this can be true of an abscess.
We are insured for £3000 a year. So these figures are just not possible for us.
We know from a Facebook group that is only for vizslas with MMM or possibly having. It is invite only. People there obviously have a lot of knowledge and it's a hard thing to identify. Bit pictures and reactions are all identical with varying extremes on the page. The wife does this. I don't do Facebook.
I know that it can help to treat with steroids to reduce the muscle loss. But our vets won't give them him. We are in the very real situation of having a dog that can't eat as his mouth won't work. So the outcome will be death or feed tube. We won't do a feeding tube, so it's death.
I really can't understand why the vet won't try steroids, they said they have side affects but no details. People on the FB page said their vets tried steroids as they agreed it was fitting with internet research etc. Ours won't but don't really say why.
I look at it with the view his prognosis isn't looking good, so best to try it and see if it helps. At the moment we are doing nothing but listening to theories that come with huge costs. Turns out £3000 doesn't do much for a poorly dog. We have never claimed. 2 or 500 pounds here and there is ok. But thousands we don't have.
My question is, have any vets dealt with this? Can someone tell me why steroids are so bad in this situation?

I have now said to my wife, find out where these people's vets are and we will travel. I just thought I'd throw it out here just incase we can get answers to the above questions or any advice.
I appreciate you taking the time to read this.
Some pics of what he looks like when not well. The solo pic you can see the loss on his right side of his head. The left side is the same now the swelling has gone.
 

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Our Viz is 4 in August. Has always been healthy and is a strong dog.
He got what we thought was an eye on infection in his right eye in march 2021 Swells up and looks sore. He was shivering like he had a fever and was looking pretty sorry for himself. Treated with antibiotic and metacam and went away. This happened again in July 2021 and same signs but I noticed he couldn't pick things up the same with his mouth. Very slight though. Same treatment and no understanding of what it could be by the vet.
June 2022 his left eye swelled up like the second time in the right. Metacam and antibiotics again.
I noticed his jaw not being the same. Can't carry a sock anything this time. I had a good look at his gums and teeth. All looks perfect and uniform gum colour. Press his face and head anywhere and no pain reaction. If I open his mouth over half way he yelps. So is in pain. Took him to the vet and she checked him over and agreed with my check over. I suggested MMM ( as the vets were inconclusive of his previous visits). Also I googled vizsla can't open his mouth properly and swollen eye. The vet said his head has suffered muscle loss one side but I thought it was the other side swollen. She admitted she knew nothing about the MMM but said he was obviously losing muscle and it looked fitting. Had a blood test visit was £290. 3 weeks later test was inconclusive/borderline.
He made a bit of recovery over the last few weeks with retrieving and carrying things. But he still can't yawn properly. Last night his eye has swollen a little. Mouth is not working properly and can't carry anything. Wet food to eat as well. Where his spine meets his head, the bone is becoming more prominent. Between his ear and eyes is starting to sink inwards. So he is losing muscle fast. Now I really think we have an issue with MMM. The muscle loss in 4 weeks is alarming to see.
Again speak to the vet, she isn't sure as she hasn't ever seen it and so we seem to twiddle our thumbs again. She spoke to the pet hospitals. Muscle biopsy that was suggested the labs can't test. Then derby want to carry out tests quoting £4500-£6500 for diagnostics. Donnington was looking less invasive and wanted to check him when he was looking ill. We were told £350. This is doable, but that was just to walk in the door. Then if the specialist wants him checking they said £3400 on top and pay in full before leaving.
Solihull were yet to give a price. But it's to far. They all said they were very interested in treating him. No discounts offered for them learning or researching though. I did ask.
Abscesses and infections have been said. But it swaps sides and we are getting muscle loss. So I don't know if this can be true of an abscess.
We are insured for £3000 a year. So these figures are just not possible for us.
We know from a Facebook group that is only for vizslas with MMM or possibly having. It is invite only. People there obviously have a lot of knowledge and it's a hard thing to identify. Bit pictures and reactions are all identical with varying extremes on the page. The wife does this. I don't do Facebook.
I know that it can help to treat with steroids to reduce the muscle loss. But our vets won't give them him. We are in the very real situation of having a dog that can't eat as his mouth won't work. So the outcome will be death or feed tube. We won't do a feeding tube, so it's death.
I really can't understand why the vet won't try steroids, they said they have side affects but no details. People on the FB page said their vets tried steroids as they agreed it was fitting with internet research etc. Ours won't but don't really say why.
I look at it with the view his prognosis isn't looking good, so best to try it and see if it helps. At the moment we are doing nothing but listening to theories that come with huge costs. Turns out £3000 doesn't do much for a poorly dog. We have never claimed. 2 or 500 pounds here and there is ok. But thousands we don't have.
My question is, have any vets dealt with this? Can someone tell me why steroids are so bad in this situation?

I have now said to my wife, find out where these people's vets are and we will travel. I just thought I'd throw it out here just incase we can get answers to the above questions or any advice.
I appreciate you taking the time to read this.
Some pics of what he looks like when not well. The solo pic you can see the loss on his right side of his head. The left side is the same now the swelling has gone.
Oh bless, cant help you with any suggestions but wish him all the best from me chip and toby...
 
Good luck. I have no answers, but hopefully one of the vets on this forum will cast some light for you. Your dog looks somewhat depressed...
 
With a swollen eye and pain on mouth opening, I’d be putting a retrobulbar abscess ahead of MMM in terms of likely diagnosis.
Can this condition swap sides and cause muscle wasting? How would you test for this?
We are trying to get them to do blood test for infection etc today before we go to the pet hospital. Basically everything we can before the big bucks start.
Thank you for taking the time to reply.
 
Retro bulbar abscess is definitely a possibility but often causes protuberance or deviation of the affected eye and would normally only affect one eye. Pushing gently on the affected eye would probably be painful.
Masticatory muscle myosotis would not typically be painful on pressing the eyes but would often be painful on palpating the muscles of the head.
If referral and diagnostic imaging is not possible for whatever reason then treating with steroids (probably with antibiotic cover) would seem reasonable. In the short term steroids are quite safe in general providing there is no infection present but in the long term can cause liver damage, muscle weakness, excessive thirst, weight gain and skin changes.
I would suggest going back to your vet and discussing this once again. If you don’t get further ask for a second opinion. Referrals can be expensive unfortunately. If your dog is getting worse you have very little to lose by trying steroids other than these drugs confounding a diagnosis if a muscle biopsy were to be taken or to exacerbate a pre-existing infection.
There is an old but well known veterinary saying never to let anything die without feeling the benefit of corticosteroids!
 
Can this condition swap sides and cause muscle wasting? How would you test for this?
We are trying to get them to do blood test for infection etc today before we go to the pet hospital. Basically everything we can before the big bucks start.
Thank you for taking the time to reply.
No, wouldn’t typically swap sides, but then a MMM wouldn’t typically cause an inflamed eye, which the abscess would. As said, pressing the eye back into the orbit, through the closed eyelid, is painful in abscess dogs and you can feel the eye won’t go as far back.
 
Visit to the vet again yesterday. Had full bloods. Got the results yesterday and they were ok. Impressed they did it so quick.
I mentioned the above. She pressed and gave him another good look over. No pain reactions from him. Better this time as his eye was swollen for her to see properly.
We are going to Dovecote on Tuesday to see a specialist. Hopefully the 2m test a d blood results will help towards a solution or plan.
She did say again that he is unusual as all the places contacted come back within 12hrs which isn't normal apparently.
I will keep you updated with where we go on Tuesday. Maybe one day it may help someone else.
 
No, wouldn’t typically swap sides, but then a MMM wouldn’t typically cause an inflamed eye, which the abscess would. As said, pressing the eye back into the orbit, through the closed eyelid, is painful in abscess dogs and you can feel the eye won’t go as far back.
He has no pain in his eye. So it is strange. All of the pictures I have seen in confirmed cases in vizslas the one eye is swollen. Obviously when looking for it you can subconsciously pic out pictures that fit our circumstances.
Again talking about it may throw a life line.
Thank you
 
Retro bulbar abscess is definitely a possibility but often causes protuberance or deviation of the affected eye and would normally only affect one eye. Pushing gently on the affected eye would probably be painful.
Masticatory muscle myosotis would not typically be painful on pressing the eyes but would often be painful on palpating the muscles of the head.
If referral and diagnostic imaging is not possible for whatever reason then treating with steroids (probably with antibiotic cover) would seem reasonable. In the short term steroids are quite safe in general providing there is no infection present but in the long term can cause liver damage, muscle weakness, excessive thirst, weight gain and skin changes.
I would suggest going back to your vet and discussing this once again. If you don’t get further ask for a second opinion. Referrals can be expensive unfortunately. If your dog is getting worse you have very little to lose by trying steroids other than these drugs confounding a diagnosis if a muscle biopsy were to be taken or to exacerbate a pre-existing infection.
There is an old but well known veterinary saying never to let anything die without feeling the benefit of corticosteroids!
Thank you. I've now googled the steroids and it's given me some reading to look at in relation to long-term use.
I updated our visit info from the vet yesterday.
Thank you for taking the time to reply to me.
 
So specialist yesterday at Dovecote.
He said his gut is it is an auto immune problem and probably MMM.
The 2M test being border line was a good indication for him. As he said the result of the test are good. As in the fact (don't quote the numbers) 1 to 50 is clear 50 to 100 is borderline then >100 is positive.
He is having another blood test for muscle wastage now. As I think it's the only thing not checked so far. Should get this result on Thursday and then we will try steroids to treat the Viz.
I am hoping that a short course will treat it and we aren't on them long term. Apparently this can be enough to stop it and possible he won't be on them long term. So possible not the death of a dog that is to young. He did say some can have a full life. Ours is fit and healthy with no other wastage or stiffness so far. The specialist did comment on his condition as really good and is keen to keep it that way.
He did say that us still getting him to retrieve has done him good. Almost like physio for dogs. It was just our gauge of how much he was affected by his jaw. He also loves to do it.
Also contacted the breeder which is a Kennel club listed one that is where I found her. She said that his "uncle" has a skin auto immune thing and one of his sisters has diabetes. She eventually had three litters from the father and mother.
To my mind I wouldn't breed any dog with any issue at all. I've had two dogs I've not done this with and now a 3rd with this one. Quite what Kennel club do is beyond me really. I'm not really sure what to think of it now when buying a dog. I've got one that isn't Kennel club and he is fine.....
Im going to seriously consider emailing Kennel club as soon as this is confirmed fully. But I doubt it will make any difference.
I will update this thread as we go and learn of the future.
Hopefully no one will ever need it, but it may be a reference for someone one day.
The Facebook group for the vizlas has been an extremely helpful page. I would say a great deal of knowledge and no he said she said. It's actual owners that have gone through it. They didn't advise step 10 before step 1 either. Nobody wants this to be wrong with a dog. Much better it's something else.
I do think that it would be a good page for vets to see. Lots of pictures and technical info that means nothing to me. But my wife understands it she is a clinical nurse specialist in haemotology. I guess with all pages you have filter out junk. But can often give food for thought.
 
Being kennel club registered isn’t a guarantee, it’s the subsequent elective health screening breeders do which should be your guide, especially with breeds with known about predispositions.
Glad you’ve got a glimmer of hope ahead now with the diagnosis and treatment.
 
Being kennel club registered isn’t a guarantee, it’s the subsequent elective health screening breeders do which should be your guide, especially with breeds with known about predispositions.
Glad you’ve got a glimmer of hope ahead now with the diagnosis and treatment.
So should I inform them of the condition? Basically I don't want anyone else having this issue I can do the correct thing.
 
So we started steroids on Friday night.
Obviously we are with the dog all the time as we were made aware if it was infections and suppressing his immune system isn't good.
Basically after 3 doses his head swelling has reduced completely. The sad thing is, you can see how much muscle he has lost. But he did pick up a 2ltr water bottle yesterday. So opened his mouth a lot farther than the last few weeks.
I'm not saying it's a cure as Im well aware it could naturally be happening and we are just hoping for/looking for what we want to see.
He did drink a lot yesterday. But he was always in the sun. He loves it. He had to go out once in the night. So far so good on side effects.
 

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So should I inform them of the condition? Basically I don't want anyone else having this issue I can do the correct thing.
Who, the breeder of KC? I thought you said you had told the breeder? It would be their conscience and nothing else stopping them but I would inform them if it’s something hereditary. KC no point, they wouldn’t have any power to do anything.
 
Who, the breeder of KC? I thought you said you had told the breeder? It would be their conscience and nothing else stopping them but I would inform them if it’s something hereditary. KC no point, they wouldn’t have any power to do anything.
Ok thank you for that. We will inform the breeder. I was kind of hoping you could inform Kennel club so that it's easy for them/other owners/potential breeders see a history of the blood lines from his relatives. Maybe put people off. 🤷
We asked the breeder of any history. I wouldn't say it's MMM until the specialist confirms it. But I don't think they can. I think it's just labelled an auto immune muscle issue that looks very much like MMM. It's all very vague.
 
2 weeks into the steroids.
More loss of muscles in his face. Full jaw bone can be seen all the way into the head. He has lost his muscle on his body as well. But only really noticed it when we put his collar on from 4 weeks ago.
Mood has changed. He is a lot less lively. Doesn't play with the other dog anymore.
Lost his young play and sleeps a lot more. Zones out at times when sat too.

He now drinks loads and obviously pees a lot more. I'd say toilet every 2 hrs and it's a big one too. This is all night as well . Poo is generally soft as well. His appetite is huge and constantly looks for food. Which isn't like him.

His mouth is working and he can carry things again. So this is a great improvement. Kind of hoping that it keeps work as we start to reduce the dose in 2 weeks time. Along with him needing to pee less. This would be a welcome event for me.
 
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