Ivermectin, for the interested

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From India, concerning healthcare workers:



iirc, the cost per Pfizer shot that the EU contracted for was in the region of €17.50+ (For each person in the EU).

It would appear that the measures used in India are rather more cost effective per head, especially given that those taking the Ivermectin are not capable of further spread of the illness, according to the study. Rather similar to what Dr Hector Carvallo in Buenos Aires was suggesting more than a year ago now.

Cui buono? 🤔
 
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Sounds like a no brainer. That's a pretty impressive results whether it has been peer reviewed or not. And look at the cost, given they have 1.3 billion people to get through.
 
So it costs a third of a cent to safely dose a human being with Ivermectin...and the ever swelling body of meta data says one treatment* causes an 80% reduction in patient susceptibility to SARS-CoV-2.

One South African Doctor absolutely nailed it with a quip worded like this:

"What is the worst that could happen if we dose the whole population with Ivermectin? We would have a parasite-free populace. And the probability is we would simultaneously arrest covid impact..."

*where one treatment is defined as weight appropriate dosage taken orally twice, three days apart.
 
Sounds like a no brainer.


Side-effects
General side-effects
Common or very common
Skin reactions

Specific side-effects
Frequency not known
With oral use

abnormal sensation in eye; anaemia; appetite decreased; asthenia; asthma exacerbated; chest discomfort; coma; confusion; conjunctival haemorrhage; constipation; diarrhoea; difficulty standing; difficulty walking; dizziness; drowsiness; dyspnoea; encephalopathy; eosinophilia; eye inflammation; faecal incontinence; fever; gastrointestinal discomfort; headache; hepatitis; hypotension; joint disorders; leucopenia; lymphatic abnormalities; Mazzotti reaction aggravated; myalgia; nausea; oedema; pain; psychiatric disorder; seizure; severe cutaneous adverse reactions (SCARs); stupor; tachycardia; tremor; urinary incontinence; vertigo; vomiting


COMMON side effects
If experienced, these tend to have a Severe expression i
Sorry, we have no data available. Please contact your doctor or pharmacist.

If experienced, these tend to have a Less Severe expression i
Itching
Joint Pain
Fever
A Skin Rash
Swollen Lymph Nodes
Fast Heartbeat
INFREQUENT side effects
If experienced, these tend to have a Severe expression i
Corneal Opacity, A Scarring Disorder That Results In Clouding Of The Cornea Of The Eye
Pink Eye
Accumulation Of Fluid In The Tissues Of The Eyelid
Inflammation Of The Corneal Edge Of The Eye
If experienced, these tend to have a Less Severe expression i
Dizziness
Fluid Retention In The Legs, Feet, Arms Or Hands
Puffy Face From Water Retention
Headache
Nausea
Diarrhea
RARE side effects
If experienced, these tend to have a Severe expression i
Low Levels Of White Blood Cells
Increased Eosinophils In The Blood
Hemorrhage From The Conjunctiva Of The Eye
Low Blood Pressure
Worsening Asthma
Inflammation Of The Liver Called Hepatitis
A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis
A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
Seizures
High Amount Of Bilirubin In The Blood
Abnormal Liver Function Tests
Mazzotti Reaction, A Reaction Resulting From The Treatment Of A Parasite Infection
If experienced, these tend to have a Less Severe expression i
Orthostatic Hypotension, A Form Of Low Blood Pressure
Constipation
Hives
Muscle Pain
Drowsiness
Sensation Of Spinning Or Whirling
Low Energy
Muscle Tremors
Decreased Appetite
Vomiting
Intense Abdominal Pain



It is important to note that, to-date, our analysis has identified:

No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
A concerning lack of safety data in the majority of studies.
We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.



 

Side-effects
General side-effects
Common or very common
Skin reactions

Specific side-effects
Frequency not known
With oral use

abnormal sensation in eye; anaemia; appetite decreased; asthenia; asthma exacerbated; chest discomfort; coma; confusion; conjunctival haemorrhage; constipation; diarrhoea; difficulty standing; difficulty walking; dizziness; drowsiness; dyspnoea; encephalopathy; eosinophilia; eye inflammation; faecal incontinence; fever; gastrointestinal discomfort; headache; hepatitis; hypotension; joint disorders; leucopenia; lymphatic abnormalities; Mazzotti reaction aggravated; myalgia; nausea; oedema; pain; psychiatric disorder; seizure; severe cutaneous adverse reactions (SCARs); stupor; tachycardia; tremor; urinary incontinence; vertigo; vomiting


COMMON side effects
If experienced, these tend to have a Severe expression i
Sorry, we have no data available. Please contact your doctor or pharmacist.

If experienced, these tend to have a Less Severe expression i
Itching
Joint Pain
Fever
A Skin Rash
Swollen Lymph Nodes
Fast Heartbeat
INFREQUENT side effects
If experienced, these tend to have a Severe expression i
Corneal Opacity, A Scarring Disorder That Results In Clouding Of The Cornea Of The Eye
Pink Eye
Accumulation Of Fluid In The Tissues Of The Eyelid
Inflammation Of The Corneal Edge Of The Eye
If experienced, these tend to have a Less Severe expression i
Dizziness
Fluid Retention In The Legs, Feet, Arms Or Hands
Puffy Face From Water Retention
Headache
Nausea
Diarrhea
RARE side effects
If experienced, these tend to have a Severe expression i
Low Levels Of White Blood Cells
Increased Eosinophils In The Blood
Hemorrhage From The Conjunctiva Of The Eye
Low Blood Pressure
Worsening Asthma
Inflammation Of The Liver Called Hepatitis
A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis
A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
Seizures
High Amount Of Bilirubin In The Blood
Abnormal Liver Function Tests
Mazzotti Reaction, A Reaction Resulting From The Treatment Of A Parasite Infection
If experienced, these tend to have a Less Severe expression i
Orthostatic Hypotension, A Form Of Low Blood Pressure
Constipation
Hives
Muscle Pain
Drowsiness
Sensation Of Spinning Or Whirling
Low Energy
Muscle Tremors
Decreased Appetite
Vomiting
Intense Abdominal Pain



It is important to note that, to-date, our analysis has identified:

No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
A concerning lack of safety data in the majority of studies.
We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.




I notice death isn't a common side effect of Ivermectin.
 

Side-effects
General side-effects
Common or very common
Skin reactions

Specific side-effects
Frequency not known
With oral use

abnormal sensation in eye; anaemia; appetite decreased; asthenia; asthma exacerbated; chest discomfort; coma; confusion; conjunctival haemorrhage; constipation; diarrhoea; difficulty standing; difficulty walking; dizziness; drowsiness; dyspnoea; encephalopathy; eosinophilia; eye inflammation; faecal incontinence; fever; gastrointestinal discomfort; headache; hepatitis; hypotension; joint disorders; leucopenia; lymphatic abnormalities; Mazzotti reaction aggravated; myalgia; nausea; oedema; pain; psychiatric disorder; seizure; severe cutaneous adverse reactions (SCARs); stupor; tachycardia; tremor; urinary incontinence; vertigo; vomiting


COMMON side effects
If experienced, these tend to have a Severe expression i
Sorry, we have no data available. Please contact your doctor or pharmacist.

If experienced, these tend to have a Less Severe expression i
Itching
Joint Pain
Fever
A Skin Rash
Swollen Lymph Nodes
Fast Heartbeat
INFREQUENT side effects
If experienced, these tend to have a Severe expression i
Corneal Opacity, A Scarring Disorder That Results In Clouding Of The Cornea Of The Eye
Pink Eye
Accumulation Of Fluid In The Tissues Of The Eyelid
Inflammation Of The Corneal Edge Of The Eye
If experienced, these tend to have a Less Severe expression i
Dizziness
Fluid Retention In The Legs, Feet, Arms Or Hands
Puffy Face From Water Retention
Headache
Nausea
Diarrhea
RARE side effects
If experienced, these tend to have a Severe expression i
Low Levels Of White Blood Cells
Increased Eosinophils In The Blood
Hemorrhage From The Conjunctiva Of The Eye
Low Blood Pressure
Worsening Asthma
Inflammation Of The Liver Called Hepatitis
A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis
A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
Seizures
High Amount Of Bilirubin In The Blood
Abnormal Liver Function Tests
Mazzotti Reaction, A Reaction Resulting From The Treatment Of A Parasite Infection
If experienced, these tend to have a Less Severe expression i
Orthostatic Hypotension, A Form Of Low Blood Pressure
Constipation
Hives
Muscle Pain
Drowsiness
Sensation Of Spinning Or Whirling
Low Energy
Muscle Tremors
Decreased Appetite
Vomiting
Intense Abdominal Pain



It is important to note that, to-date, our analysis has identified:

No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
A concerning lack of safety data in the majority of studies.
We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.




Some simple questions in reply:

Is SARS-CoV-2 lethal to approx 1-in-a-1000 in world population?

How many doses of Ivermectin have been administered since the mid eighties? [hint: you will need nine zeros after your integers stop]

How many people have been killed by Ivermectin? [you won't need many zeros for this answer]

Remdesivir is widely prescribed, latterly for covid. How many has it killed?

EDIT- but these rhetorical questions which point to self-evident observations are as nothing to empirical science: Dr Tess Lawrie is emphatic that Ivermectin is efficatious and backs that up with data:

 
By the time
Some simple questions in reply:

Is SARS-CoV-2 lethal to approx 1-in-a-1000 in world population?

How many doses of Ivermectin have been administered since the mid eighties? [hint: you will need nine zeros after your integers stop]

How many people have been killed by Ivermectin? [you won't need many zeros for this answer]

Remdesivir is widely prescribed, latterly for covid. How many has it killed?

EDIT- but these rhetorical questions which point to self-evident observations are as nothing to empirical science: Dr Tess Lawrie is emphatic that Ivermectin is efficatious and backs that up with data:



Remdesivir (Gilead trade name Veklury) was certainly not widely prescribed. It was developed as a potential therapy for Ebola, for which, in trials, it proved not as effective as other treatments, so was dropped.

From Gilead: As of January 2020, we were not actively manufacturing Veklury. The manufacturing supply chain was scaled to periodically make small amounts of product for a compound in early development. We had inventory of finished product to treat just 5,000 patients.

Since then, we have proactively and rapidly scaled our supply chain. We have worked over the past months to improve processes, shorten timelines and increase volumes as we work to bring Veklury to patients as soon as possible. By the end of June, we produced more than 190,000 treatment courses.

Our goal is to produce a total of:

More than 2 million treatment courses by December 2020
Several million treatment courses in 2021, if required


It has since been "repurposed" as having some effect against SARS-CoV-2 replication.

It is known to be risky for people with liver or kidney impairment.

You can read the UK policy here: https://www.england.nhs.uk/coronavi...for-people-hospitalised-with-covid-19-v2-.pdf

Basically, you will only get it if your consultant thinks it might be worth a try, but you have to first be hospitalised, with diagnosed Covid-19, have pneumonia requiring supplemental oxygen, have reasonably working kidneys and liver, not have had symptoms for more than ten days, not be highly likely to recover, and not be unlikely to survive. Given the chances of death, once hospitalised, with pneumonia and needing oxygen, I'd say the benefits probably outweigh the risks. Likewise if you've caught Ebola (though better treatments are available).

By the way, it costs the NHS £340 per 100ml vial, and a full course requires seven vials (£2,380). So, lets say Gilead did make 2 million courses last year, that's a cool £2.38 billion's worth.

Likewise Ivermectin is only authorised for human use in treating parasitic worm infections such as river blindness, and scabies, where, again, the benefits probably outweigh the risks. Which are real. And so far, no studies have conclusively demonstrated its supposed efficacy, but the "Together" trial that I referenced hopefully might change that soon.

As for the cult of personality, it seems that there's a lot of that going on still.
 
Hence why we have risk-benefit analysis.

And extremely good surveillance in the UK that can expose these sorts of unforeseen side effects, and identify new variants, etc.

So, now that these clotting issues with AZ have been identified, and found to be most worrying with young female people (contraceptive pill involvement suspected), who are at low risk of severe illness form Covid 19, particularly now that over half of us have had at least one vaccination already, and by analogy probably also with Johnson and Johnson/Janssen, and Sputnik, and the Chinese ones, that use the same technology, our young cohort, soon to be vaxxed, will be offered the mRNA products in preference.

The risk, for them, of taking AZ, seem to outweigh the benefits. So, this country being well prepared, they will be offered the alternatives.

What's the betting that if say 30 million plus of us had instead been dosed with Ivermectin, that with our surveillance, some untoward problems might have been discovered that made the blood clot risk of AZ seem of very little consequence by comparison. And revealed whether the stuff was of any worth as a prophylactic ?
 
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What's the betting that if say 30 million plus of us had instead been dosed with Ivermectin, that with our surveillance, some untoward problems might have been discovered that made the blood clot risk of AZ seem of very little consequence by comparison. And revealed whether the stuff was of any worth as a prophylactic ?

That, surely, is the whole point.

3.5 BILLION doses of Ivermectin have been administered.

The safety factory based on 4 decades of prescription declare it safer than other anti virals.

And you utterly ignore Dr Tess Lawrie's work confirming Ivermectin efficacy. Why is that?
 
That, surely, is the whole point.

3.5 BILLION doses of Ivermectin have been administered.

The safety factory based on 4 decades of prescription declare it safer than other anti virals.

And you utterly ignore Dr Tess Lawrie's work confirming Ivermectin efficacy. Why is that?
Ivermectin was not developed as an antiviral.

It is an anthelmintic. Any antiviral properties have only, as yet, been identified in in-vitro studies of non-representative monkey kidney cells, using concentrations vastly higher than human dosage limits. 35 times higher.

Study e.g. Ivermectin: an award-winning drug with expected antiviral activity against COVID-19 for some insight. Published 10 Jan 2021.

Merck themselves are crystal clear that, at dosage levels allowed for humans, there is "No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;" It's not as if they are a disinterested party, if it does turn out to be of some use they would certainly stand to benefit financially from producing it.

On which point, I made a schoolboy error, Gilead may already have sold £4.8 billion's worth of Remdesivir in 2020, (at government negotiated prices, much higher prices otherwise).

What is this Ivermectin "safety factor" of which you speak ? References please. Still advocate eating horse wormer paste, as you have done ?

As for what attention to pay to Dr Lawrie, or his hero Tess Lawrie (connection ?) and his scarcely veiled conspiracy theories, well I, as always, have an open mind. Besides, she is merely a meta analyst, one of many. Others are actually researching this stuff for real.

So, who do you trust more, a youtube personality, or ???
 
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Ivermectin was not developed as an antiviral.

It is an anthelmintic.

That is stating facts that have been in the public domain since the 80s. Ummm...we all know this.

antiviral properties have only, as yet, been identified in in-vitro studies of non-representative monkey kidney cells, using concentrations vastly higher than human dosage limits. 35 times higher.

Just untrue.

Can't really help you here. Links to FLCCC data, multiple global studies, Dr Campbell's work, Dr Tess Lawrie's work all falling on deaf ears. Very odd.


Merck ... if it does turn out to be of some use they would certainly stand to benefit financially from producing it.

Once again. I am utterly puzzled. You do know that Ivermectin is off licence?

Any lab is free to make it. Correct, Merck are already making it, but will probably have no market for their expensive packaging if labs across Asia start making the stuff in volume.


Still advocate eating horse wormer paste, as you have done ?

I corrected you on this once before. I will give it one more try: I am not advocating that anyone consume anthelmintics formulated for equine use. Nor have I ever taken any.

But persuaded that Ivermectin can prevent death in those susceptible to SARS-CoV-2, I think households that do not source safe stocks of that drug are placing rather too much faith in the governments' strategies.
 
I corrected you on this once before. I will give it one more try: I am not advocating that anyone consume anthelmintics formulated for equine use. Nor have I ever taken any.

But persuaded that Ivermectin can prevent death in those susceptible to SARS-CoV-2, I think households that do not source safe stocks of that drug are placing rather too much faith in the governments' strategies.
So, pray, where might a household source "safe stocks" of Ivermectin, in the UK ? Have you, for example, persuaded the London School of Hygiene and Tropical Medicine that you and your household have contacted a rare disease that requires treatment with oral Ivermectin, to stockpile ?

I place rather more faith in the NHS to look after me than in Immanuel, and the book of Isaiah (rather robust stuff).

So, perhaps you'd like to have a go at your own meta-analysis, well here's a starter for ten (actually 179). Search of: ivermectin - List Results - ClinicalTrials.gov

So, you place your faith in the musings of Dr. John Campbell, who has a youtube channel to support. As an "independent developer.

Well, he's been a "doctor" for all of four years nine months. Studied for a PhD in teaching nurses 2011- 2013, presumably it took him several more years to write up his thesis and bag it. Trained nurses and still works as one in A+E. Collected a lot of bits of paper over the years, all credit.

His profile: https://uk.linkedin.com/in/dr-john-campbell-5256223b

Experience
Independent developer
Independent developer
4 years 9 months

Doctor
Sep 2016 - Present4 years 9 months

Carlisle, UK

Educational resource developer
Sep 2016 - Sep 20161 month

Carlisle, UK

Development of low cost multimedia educational resources for health care professionals

Independent Graphic
Resource developer
Independent
Sep 2016 - Present4 years 9 months

Carlisle, United Kingdom

Video, podcasts, multimedia, online streaming, e books as well as conventional writing and publishing. Developing new ways to teach through diagrams and infographics.

NHS Graphic
Staff Nurse, Accident and Emergncy
NHS
Apr 2016 - Present5 years 2 months

Clinical work in the A and E department.

University of Cumbria Graphic
Nurse Tutor then Senior Lecturer
University of Cumbria
Sep 1989 - Sep 201627 years 1 month

Teaching under and post graduate nurses.

Education
The University of BoltonThe University of Bolton Graphic
The University of Bolton
Doctor of Philosophy (Ph.D.)Teaching bioscience in national and international nurse education.
2011 - 2013

Lancaster UniversityLancaster University Graphic
Lancaster University
MScHealth Science
1996 - 1998

Health Science

Lancaster UniversityLancaster University Graphic
Lancaster University
Post Graduate Certificate in PharmacologyPharmacologyGood
1995 - 1997

The Open UniversityThe Open University Graphic
The Open University
BScBiology and health2.1
1986 - 1991

Biology ad Health

The Open UniversityThe Open University Graphic
The Open University
Bachelor of Arts (B.A.)
1986 - 1990

York St. John UniversityYork St. John University Graphic
York St. John University
Certificate in EducationNurse EducationGood
1988 - 1989

Liverpool School of Tropical MedicineLiverpool School of Tropical Medicine Graphic
Liverpool School of Tropical Medicine
Certificate in Tropical DiseasesTropical Diseases
1986 - 1986

University of LondonUniversity of London Graphic
University of London
Diploma in Nursing
1982 - 1984
 
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Curious, couldn't find him. So maybe not a medical doctor ?

Dr. Tess Lawrie.





EBMCSQUARED CIC - Overview (free company information from Companies House) Incorporated 1 April 2021.

The Team
Theresa Lawrie
Director

Tess (MBBCh, DFSRH, PhD), as director of E-BMC Ltd, is committed to improving the quality of healthcare through rigorous research. Her range of research expertise, based on research experience in both developing and developed countries, uniquely positions her to evaluate and design research for a variety of healthcare settings. Tess is a frequent member of technical teams responsible for developing international guidelines. Her peer-reviewed publications have received in excess of 2000 citations and her ResearchGate score is among the top 5% of ResearchGate members.


Ewelina Rogozińska
Project Manager

Ewelina (MSc, PhD) is an experienced systematic reviewer whose expertise includes the methodology of meta-analyses using individual participant and test accuracy data. She also has considerable experience in managing evidence synthesis projects and their teams.

Therese Dowswell


Systematic Reviewer
Therese, PhD BSc (econ), is a systematic reviewer with considerable experience in Cochrane and GRADE methodology. Previously she worked with the Cochrane Pregnancy and Childbirth Group in Liverpool where she was frequently involved in international healthcare guideline development.
 
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you place your faith in the musings of Dr. John Campbell, who has a youtube channel to support. As an "independent developer.

Once again, I really do not know where you whistle this stuff up. Who ever declared Campbell to be a "developer"?

His qualifications and experience look a good fit for data analysis in the medical field.

His presentation style is to reveal the data available in public domain. If he avers an opinion, he prefaces that bit with an appropriate disclaimer. Mostly it is just data.
 
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