Well I had a 204 ruger about 10 yrs ago loved it I'm its biggest fan sold IT bought a 243 win ,but I now have a ruger no 1 in 220 swift ,I have tried and both these in the field ,I have a few magazines of rod and gun from 1939 to the 1940s ,one them has a test of a 220 swift on red deer in Scotland,in 2 yrs the stalker shot 64 reds ,one at 264 cyards and it went down like a sack spuds ,he so impressed with kills with the 220 swift ,the rifle was a Winchester 54 ,with a 4 power Zeiss and Winchesters 48 grn ammo ,in which I have a box of myself , 204 r better ammo availability light recoil a super cal ,220 swift a beast ,better choice of heads if reloading but not ammo , both flat shooting and very accurate cals ,anyway what's wrong with the 22 250 rem ,best of luck with your choice