All semi auto .22s have their issues, but here's my take. Avoid the Anschutz semi autos, they're cheap for a reason. Pigs to strip and reassemble too, with accuracy little better than minute of barn. No doubt someone somewhere has one that is bench rest accurate and never gets dirty, but he's pretty much on his own. I owned 2 of the damned things and they were rubbish.
The Derby Open gallery rifle competition, held in June, has about 100 competitors shooting multiple events over 2 days. Nearly all of those competitors, and particularly the high scorers, use Ruger 10/22s. A rifle made in such huge numbers at such a low price is bound to have a percentage of lemons, but most will shoot adequately, and most custom versions will shoot very well. What's more, every single part can be changed, customised, or replaced with ease. Most will cycle subsonics with ease. They're easy to strip and clean too.
The best alternative for a standard looking rifle is without a doubt the CZ range. If you put a sound moderator on a semi auto the cleaning regime becomes a regular necessity as the back pressure clags up the action in short order.