Ivermectin, for the interested

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The answer is in my previous post...yes.

For the absence of doubt, I will re-post the link to NICE bnf below:

Perhaps I'm mistaken, but that does seem to say that oral ivermectin is not licensed for human use in the UK - which is currently my understanding also.
 
Perhaps I'm mistaken, but that does seem to say that oral ivermectin is not licensed for human use in the UK - which is currently my understanding also.

My bad. Its oral use is unlicensed. However...

...NICE supplies oral dosing for Ivermectin, and specifically lists Stromectol as as proprietary variant

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And both the NICE and GMC allow for the prescription of unlicensed pharmaceuticals.

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My bad. Its oral use is unlicensed. However...

...NICE supplies oral dosing for Ivermectin, and specifically lists Stromectol as as proprietary variant

View attachment 190897


And both the NICE and GMC allow for the prescription of unlicensed pharmaceuticals.

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Thanks for clarifying this aspect, Zambezi.

Cannot help but wonder how Ivermectin would have been received if it's efficacy was as laid out below AND it was worth billions to big pharma? 🤔 As they say in the Godfather - it's nothing 'personal', strictly business...

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In the interests of balance, it is great to hear that we are now practically awash with vaccine of several types now in the UK, all 'free' at the point of delivery....
 
I worry that an in-some-ways laudable amateur interest in materia medica both human and veterinary, combined with a fervent desire for a cheap and convenient end to the current siege-like Covid situation might be resulting in some curious (and in my current view, unwise) quasi-therapeutic decision-making among forum members.

The world of risk:benefit analysis in the use of medicines, and the significance of product licences for substances, product licences for particular indications and such licences issued at home and/or abroad as a support (or otherwise) for decision-making when it comes to using stuff other than as licensed for UK use can be quite complex.

Thanks for clarifying this aspect...
I'm not sure in the context of this thread that anything has been clarified by Zambesi's post, other than that the understanding of licensing of medicines is not generally well-understood.

That was always a certainty.
Indeed - and it will remain one while you can't do better than repeating the opinions of a vociferous number of experts and learned bodies whose opinions nevertheless make them spectacular outliers from the current mainstream field of Covid management in places that share the UK's approach to matters medical and scientific.

The subject is interesting, and might perhaps bear fruit that the UK will find palatable in some form or other. Until it demonstrably does, however, to the considered satisfaction of those who have some kind of professional understanding of these matters...
 
...laudable amateur interest...current siege-like Covid situation...


I hear and applaud your cautious tone. Your stoic embrace of the precautionary principle will certainly not provoke harm by action.

But, as you conceed, we have endured a siege-like existence for over a year. The powers that be have not navigated a path out of this malaise.

Latterly, multiple pioneering doctors around the globe appear to have found the gate [Ivermectin]. Our way out. A way back to normal. NOT "new normal".

That is some claim! Wise govt everywhere should give that claim high and very public scrutiny.

If proven true, hurrah. Roll out the [cheap] fix. If proven untrue, draw a line. Recursively exploring different avenues shows good governance. Repeating the same things you did a year ago does the opposite.

Back to the specifics [rather than the princple of enthusiastic amateurs dabbling in arenas foreign to them being intrinsically dangerous]: Ingesting Ivermectin is very low risk. [3.7 billion doses since the 80s]. C-19 can kill. If I or a loved one get sick, I have an easy choice.
 
I hear and applaud your cautious tone. Your stoic embrace of the precautionary principle will certainly not provoke harm by action.

But, as you concede, we have endured a siege-like existence for over a year. The powers that be have not navigated a path out of this malaise. Did I I actually have to 'concede' that? I'm not aware I've ever suggested anything different?

Latterly, multiple pioneering doctors around the globe appear to have found the gate [Ivermectin]. Our way out. A way back to normal. NOT "new normal". Latterly some practitioners appear to their own satisfaction to have found something, certainly. It has not (yet?) been shown satisfactorily to be what its more-enthusiastic supporters would have us believe.

That is some claim! Wise govt everywhere should give that claim high and very public scrutiny. Some claim it is indeed; and very much more worthy of scrutiny than of being accepted de facto as truth.

If proven true, hurrah. Roll out the [cheap] fix. If proven untrue, draw a line. And in the mean time, just get yourself outside some horse-wormer, on the off-chance?
Recursively exploring different avenues shows good governance. Applying good governance to different avenues shows good governance - rather than running down them because a couple of folk have put up videos on Youtube suggesting it might be a good idea.

Repeating the same things you did a year ago does the opposite. The vaccines seem to be a change in approach since last year. We should perhaps see how that pans out for a month or three?

Back to the specifics [rather than the principle of enthusiastic amateurs dabbling in arenas foreign to them being intrinsically dangerous]: Ingesting Ivermectin is very low risk. [3.7 billion doses since the 80s]. C-19 can kill. If I or a loved one get sick, I have an easy choice. Risk associated with use of medicines is not absolute in some abstract sense, but relative to the demonstrable (or in this case, supposed) benefits. I have no idea what the reporting and recording of side-effects is like in the areas where ivermectin is most used. There is also a risk not only of harm from the drug, but harm from changes in behaviour of those who have taken it based on its supposed effects, should those effects not be as hoped for.
 
I worry that an in-some-ways laudable amateur interest in materia medica both human and veterinary, combined with a fervent desire for a cheap and convenient end to the current siege-like Covid situation might be resulting in some curious (and in my current view, unwise) quasi-therapeutic decision-making among forum members.

The world of risk:benefit analysis in the use of medicines, and the significance of product licences for substances, product licences for particular indications and such licences issued at home and/or abroad as a support (or otherwise) for decision-making when it comes to using stuff other than as licensed for UK use can be quite complex.


I'm not sure in the context of this thread that anything has been clarified by Zambesi's post, other than that the understanding of licensing of medicines is not generally well-understood.


Indeed - and it will remain one while you can't do better than repeating the opinions of a vociferous number of experts and learned bodies whose opinions nevertheless make them spectacular outliers from the current mainstream field of Covid management in places that share the UK's approach to matters medical and scientific.

The subject is interesting, and might perhaps bear fruit that the UK will find palatable in some form or other. Until it demonstrably does, however, to the considered satisfaction of those who have some kind of professional understanding of these matters...
I don't pretend to be a doctor or learned medical man, nor do I profess to be so.

It is simply that I don't personally agree with what I infer from your stance, i.e. that all those who have already died this far and whom are still falling ill - here, in our medical jurisdiction in the UK - could not possibly be given the opportunity to have have benefitted from a novel (to you, not to much of the planet) and even unconventional (to you, not to much of the rest of the planet) treatment option, had they been offered the choice, given their prognosis? Too much risk of some as yet unspecified, never mind as yet unheard of side effect, unique to us Brits, which may somehow do what, increase our risk of dying? Why too, is it when anecdotally, we have known - for some nine to ten months minimum now - of the positive effect of Ivermectin, wherever else it has been administered both as prophylaxis and treatment in the fight against Covid in all the many other countries where it has been used, is still being used and indeed adopted by other countries in the intervening period, are we so set against it? Even when, privately and less so, there are medical staff themselves here using it to safeguard themselves, can at least the option of its use not equally be offered to those in their supposed care, namely the sick and dying? These, our people?

Are all the countries who have reflected on the risk:reward:time question as to whether to 'risk' saving someone from what I understand to be a quite miserable death somehow wrong to be using what measure they have found to be effective? Or is it that we here are somehow in the 'care' of a superior form of healthcare, where it is better to die of the virus than to be saved by the 'wrong sort' of medicine, just because more reasearch is recommended?

Sounds like, a century plus on, our ' superior minds' are still keener to uphold tradition (we should be 'getting ready to climb the ladders and walk slowly toward the machine gun nests') rather than learn from the experiences of all the many others facing the common enemy, and winning by trying the 'new' workaround, all because here, the bigwigs back in the bunker deign it to be the 'right' course of action, and that the cost borne by the many (100,000 and rising) will be worth the loss.

Easier to be the superior, doing the deciding, than the unquestioning 'cannon-fodder', or so it seems from here.
What is the going rate for an ivory tower these days? Thirty pieces of silver, by the look of things. I'll wager that in the fullness of time, the comparative statistics will show which was the more effective battle strategy; too bad nobody will much care, and just shrug and say, we did our best, our wonderful system did all they could. So much for 'doing all we can to save lives'.

Your superior stance is to be applauded.

Some figures fornthe open minded, you need not trouble yourself further:

Papua New Guinea, population 8,8million. Use of Ivermectin history: population wide worm control/eradication programme, past ten years.

Number of Covid cases: 835

Number of Covid deaths: 9

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Govt response:

 
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Incidentally, our staff have got the idea (imported from Zim to Moz) that steam-inhalation and boiling-water-consumption (yes, you heard right) cure covid. The idea has really taken hold. Even the Zim government are promoting it. Quite a few people are getting scalded. Apparently, its curative claims are b0ll0cks, by the way.

On the subject of Ivermectin, white farmer friends in both Zim and SA all seem to be taking it. However, they have few other options in such broken healthcare systems. All say they would hold out for the vaccine instead if they lived in a first-world country. None has caught covid yet, but then (as I delight in pointing out to them) they haven't caught measles yet either...
 
Repeating the same things you did a year ago does the opposite. The vaccines seem to be a change in approach since last year. We should perhaps see how that pans out for a month or three?

Backing one horse to the exclusion of all else seems very unwise. Time and lives are wasted by that wait-and-see approach to individual strategies. I would urge the govt to do all trials in parallel.

Specific reasons for not just waiting to see what impact vaccines have:
  • We know that the mechanism by which all three U.K. approved vaccines operate is to provoke an immune antibody response to the signature spike protein on SARS-CoV-2
  • Data now shows that post vaccination, antibodies fall rapidly
  • If efficacy of the vaccine wanes faster than you can jab the total populace...
 
Perhaps I'm mistaken, but that does seem to say that oral ivermectin is not licensed for human use in the UK

I recall a conversation with a medical professional some time back who explained that once a drug has a full NICE licence, it is more difficult to withold is dispensation.

Thus some known-to-be-efficacious drugs may be listed as "unlicensed". Any pharmacists on SD care to comment?

Regardless, it is worth reiterating that Ivermectin is on the W.H.O.'s list of essential [anthelmintic] drugs for humans.

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UK medic Dr Andrew Hill's meta analysis of Ivermectin trials: 'worthless' to 'incomplete/insufficient' to the NICE guys deciding the fate of folks here, but interesting all the same.



The viewer comments are always worth a read, I find:


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Cui buono?? 🤔
 
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Poster "Pascal Pascal" citing where to find the high dosage trial of Ivermectin, where multiple times stronger doses than the typical dosage being now administered for Covid treatment and/or for prophylaxis, when administered to healthy patients, and was concluded to be SAFE, way back in 2002.... 🤔


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😳💵💶
 
Another viewpoint, discounted by the NICE people looking after our interests:

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I'm trying - very trying, according to the antagonists 😷
 
Poster "Pascal Pascal" citing where to find the high dosage trial of Ivermectin, where multiple times stronger doses than the typical dosage being now administered for Covid treatment and/or for prophylaxis, when administered to healthy patients, and was concluded to be SAFE, way back in 2002.... 🤔


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😳💵💶

An addendum, which I'm sure you'll be aware of having read and understood the paper cited.

ACTUAL CONCLUSION:

"High doses of Ivermectin in a small cohort of 68 individuals specifically selected from an age range of 21-45 and excluding those with any of the previously known risk factors for the tretment exhibited no more adverse reactions than the control group over a period of seven days under controlled conditions."

This testing was done as a proposed short term treatment regime for head lice, and never proceeded any further than this Stage 1 sighting trial.

IVERMECTIN SAFE FOR THIS COHORT FOR THIS USE OVER A SHORT TREATMENT WINDOW.

Not as catchy, I know, but perhaps a more comprehensive summary of the article linked.

As for the 'big pharma exploiting this for their own gain' conspiracy nonsense. the worlds big 10 pharma concerns worldwide are all publicly traded and present their earnings calls publicly. A brief skim through that data does not fill me with the impression that covid is to their benefit in revenue, bottom line, share price, bonus or profit. But maybe I'm just in too deep...
 
Sorry that doesn't make sense.

So governments around the world would rather spend incredible amounts of money on lockdowns and the consequences of lockdowns, than buy a cheap drug that could stop it. Again that doesn't make sense. If the experts in the UK decided that it was safe and advisable to offer this, don't you think the goverment would jump at the chance. Or are they all in on the conspiracy to make money from vaccines. I can see the drug companies holding back as they won't make money out of it, but they don't (or shouldn't) control the drug agencies around the world and therefore it is up to the drug agencies to approve it or not. If approved they then order it. or is that too simplistic. Again. It doesn't make sense.
Yet hydroxychloroquine is downplayed now with covid and why? it has benefits and costs almost nothing. Power and control with no regard to the end destruction of economy or human condition.
 
An addendum, which I'm sure you'll be aware of having read and understood the paper cited.

ACTUAL CONCLUSION:

"High doses of Ivermectin in a small cohort of 68 individuals specifically selected from an age range of 21-45 and excluding those with any of the previously known risk factors for the tretment exhibited no more adverse reactions than the control group over a period of seven days under controlled conditions."

This testing was done as a proposed short term treatment regime for head lice, and never proceeded any further than this Stage 1 sighting trial.

IVERMECTIN SAFE FOR THIS COHORT FOR THIS USE OVER A SHORT TREATMENT WINDOW.

Not as catchy, I know, but perhaps a more comprehensive summary of the article linked.

As for the 'big pharma exploiting this for their own gain' conspiracy nonsense. the worlds big 10 pharma concerns worldwide are all publicly traded and present their earnings calls publicly. A brief skim through that data does not fill me with the impression that covid is to their benefit in revenue, bottom line, share price, bonus or profit. But maybe I'm just in too deep...
Many thanks for this clarification, which is of benefit in furthering everyone's awareness of the actual position. It's good to know that it could potentially be safe for elements of society, for a time period that may make a significant difference to the burden on the hospitals.

We may all be 'in' a bit deeper than the depths/debts which we are comfortable!

Good news regarding the latest vaccine to be rolled on in the UK, let's sincerely hope that a one off dose will help eradicate the virus, for at least this season.
 
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Yet hydroxychloroquine is downplayed now with covid and why? it has benefits and costs almost nothing. Power and control with no regard to the end destruction of economy or human condition.
I'm (personally) not convinced about the benefits of HCQ in relation to fighting the virus in comparison to the efficacy of IVM and high dosage Vit D, having followed a bit of HCQ's 'journey' and the ups and downs of same on the way; I'm in no doubt of the efficacy of both vitamin D in the higher recommended doses, and also Ivermectin, the latter which has not as yet satisfied the principal governing bodies concerned with its adoption in either the UK or the US, though it seems to be increasing its reach to many other countries throughout the world.

To me, Ivermectin's USP is its ability to prevent the virus from replicating within the bodies of those taking it, which is a different means of defence in comparison to any of the vaccines, which each have their own differing means of stimulating the bodies' defence system into dealing with a viral attack. Irrespective of our own respective government or medical authorities position as to the desireability or otherwise of Ivermectin, in every other country where Ivermectin is being deployed its impact against the virus is clearly demonstrable. I accept that this is not sufficient proof of itself to sufficiently convince those governing bodies, but this is merely a matter of time, until studies sufficiently robust and large enough are able to convince them, it's principally just a safety issue for the novel purpose that this very well researched, trialled and approved anthelmintic medicine is preventing its roll out here and in the US, i.e. our respective bodies governing use of medicines are not yet satisfied with aspects of its safety for use in relation to SARS Cov-2 to give it approval. There is no such qualms about the use of the same drug in its role as a wormer.

On the brighter side, my understanding is that Stateside, you can ask your doctor to prescribe it, and he will not now be in trouble if he does so, you only have to ask. Here - not so much, though privately it is acknowledged that individual health workers are themselves taking the medicine, to protect themselves from the heightened risk of contracting the virus in the hospital workplace, which has been shown to be (statistically) a very significant place of transmission. Prevention, being better than cure, always.
 
There are no such qualms about the use of the same drug in its role as a wormer.
And why is this?
I think the answer to that question is also the reason why most people in this area who have a reasonable understanding of what they're talking about are not falling over themselves to get everyone to take the stuff in order to save themselves and the world from destruction.

There are no qualms because we know the risk to benefit ratio for its use as a 'wormer' is favourable. This applies not for all worms of course, but ones with particularly grave effects - blindness, for example. That in itself should give some idea that this is far from being in abstract the 'safest' anthelmintic available - i.e. it is not in abstract a 'harmless' drug; as indeed no drug is.

Might one then infer that since Covid is also serious, like River Blindness - so obviously ivermectin must also be a safe and sensible treatment and prophylactic for Covid?

Well, I'd say currently not: the missing bit currently is adequate evidence for the efficacy of ivermectin in either of those broad roles, and (as far as I can see at least) information on the incidence of side effects resulting from the suggested ivermectin regimens for those novel indications - which don't seem to resemble the standard 'worming' regimes used in geographical areas where the worms are of such an unpleasant kind that ivermectin use in humans is considered proportionate.

Finally, I might add that it is odd to think that promotion of any novel treatment strategy involving a medicine is likely to be (or at least, to remain for long) free from commercial bias or influence. It might well generally be 'off-patent' - but a vast potential new market, including for the first time in wealthier parts of the world than it's currently sold in for human use, might well be attracting the attention of chemical manufacturers and drug houses with an interest in ivermectin.
 
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