I have used Hornady ecx 50 grain and Barnes TTSX 50 Grain . ECX shot very accurate TTSX was ok both where through 1-12 twist .223 . Obviously a 22-250 could send them faster and that would help . I found the TTSX less accurate and not great at longer ranges , ECX very accurate ( rabbit head shots at 200 was easy enough ) I have had them both on CWD and recommend keeping the range to more like 100 and go for the better placement ( i will in future) I lost one to a boundary issue fairly close and had one run around like it wasn't hit for too long for my liking till another shot dropped it . 22-250 with TTSX with a fast twist i suspect would be very much better . Twist rate will depend on how you find things , i plan to re-barrel to 1-8 and likely Ackerly the .223 perhaps ?