The challenge comes with thin lightweight barrels, especially when they are soldered to another barrel like in a combination gun or double.
Because they are attached down one side they warp towards the side to which they are attached.
A double rifle is regulated so you shoot one barrel followed by the other and the warping counter balances.
In a combination gun, first shot from rifle barrel is on target, 2nd goes an inch high, 3rd about 4 inches high. When zeroing you take your time and make sure It is properly cool between shots.
Does this matter. Well in the field a double game rifle is shooting big game at pretty close range. Two quick shots are pretty much all you get, and if you do reload, shots 3 and 4 are going to be up close and MOA is an irrelevance.
I use a 7x65r as my main stalking rifle. I make sure that the first shot counts, and I have shot plenty of deer with it out to 200m. I have reloaded and taken a 2nd deer on occasion and an inch high doesn’t matter.
With a hunting rifle, 99% of shots are from a cold barrel, and I always work on a cold barrel zero, and when working up loads I take my time to let barrels cool.