Compromise, compromise.....
I'm still fiddling with copper and calibers nearly 10 years after having started playing with them, but then I was always fiddling with lead for the 10 years before that

. You're always going to have to compromise something, it's up to you what you want that compromise to be.
TTSX/LRX are a great bullet when driven sufficiently quickly, with TV not dropping below about 2400 fps. A hilar shot drops a deer on the spot. Lung shot sees it run and drop - how far is dependant on calibre, species, exact placement and state of alert. There is evidence at the shot site of a strike and very often a reasonable blood trail. I get nervous about neck shots as little margin for error with no fragmentation and I get nervous about ricochet with 100% weight retention and 100% record of pass through.
I have been using Yew Tree for some time now. 80gr 6mm in 6XC at 3240fps perfect on Roe and Muntjac - most drop to shot even if the chest shot is not hilar. Had very few made it much further than 5m and carcass damage is negligible but internals are cut to ribbons. Fallow with the 6mm die, but all have run 30m plus unless hilar hit precisely, one ran 80m. 6.5x47 Lapua with 114gr YT at 3000fps is better for run distances, but they are still running unless hilar or neck hit. In terms of comparison with the TTSX/LRX the YT are more accurate, they make more of a mess of more of the internals, I don't worry about neck shots due to the fragmentation and extra margin for error and I don't worry about ricochets. I'm very happy shooting deer down to pretty low TV's as I trust the expansion/fragmentation - the point at which I wouldn't trust them is much further than I'm prepared to fire a first shot at. The down side is I very rarely get a blood trail - in fact you're very pushed to find any evidence at the shot site at all. Thankfully I stalk with a dog at heel and he seems able to follow up very quickly to find them in woodland/heavy cover, but you would struggle without one at times.
So my compromise with the YT is blood trails but I have a way to overcome that with the dog. The answer is to stick the bullet in the right spot to start with - ie. hilar, but if you're off for some reason just watch the follow up - it might take a while if you're in the woods.
It might be that a larger caliber solves that issue. Perhaps a 308 would give a bigger exit and a blood trail - but I don't have one of those...