I can't really say because I do not have a 45-70 however some Sika will run up to 200 yds with their heart lying at the point that they were shot at. All Sika I heart shot with a 170gr 30-30 just ran away, 100yds was normal even for a calf. The 160gr. Leverrevolution dropped em a bit quicker. A Sika hind is only somewhere around 5-6" wide at the heart area, many hunting bullets are a bit hard and don't expand properly or don't leave much energy in the body. 156gr Lapua mega from a 6.5x55 is another example, very slow and made for taking down Moose, distributing the energy over say 2-3ft of penetration, it possibly leaves less energy in a lightweight heart shot sika than a hornet that doesn't exit.
Everything slow and heavy seems to just punch a hole through, yes they will die 100%...but somewhere else. We just cannot afford to let them run in certain places because they would end up on another persons land in many cases we could not retrieve the deer.
The 22-250 seems to drop these lighter deer just like struck by lightning, maybe the temporary cavity upsets spine for a while...I don't know. We have seen the same with a swift and 55gr v-max for example. My 243 with a 80gr SP varmint bullet does not have the magic, never tried anything lighter.
I don't think a 22-250 or a swift is a proper deer cartridge and also see a 243 as marginal but it doesn't change that I have used the 22-250 on Sika for a while and only changed because I didn't want to push my luck.
If you read on German forums, they use the 9.3x62 quite often on Roe deer and also often complain about runners, not a slouch either with a 270gr bullet. My take, wrong bullet, wrong cartridge for roe.
edi